Annotation Overview for fig|66692.3.peg.2019 in Bacillus clausii KSM-K16:
Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)

current assignment	Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)	EC Number	1.3.3.1
taxonomy id	66692	contig	66692.3:NC_006582 (4,303,872bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPInterProScanRadarPPSearchGram negative CELLOGram positive CELLOProDomPDB
FigFam	FIG001054
data base cross references (dbxref)	NCBI: 56910339 NCBI: 81822095 NCBI: 56964096 RefSeq: YP_175827.1 UniProt: Q5WFJ4 CMR: NTL03BC2323 UniProt: PYRD_BACSK

Annotation History (history of similar genes)

Date	Annotator	Annotation
9/28/2005	ncbi	Set FIG function to dihydroorotate dehydrogenase catalytic subunit
10/7/2005	automated_assignments	Set FIG function to Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)
3/28/2006	RossO	Set FIG function to Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)

We have assigned the function "Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1)" to the encoded protein. The protein occurs in 1 subsystem: "De Novo Pyrimidine Synthesis". In "De Novo Pyrimidine Synthesis", it appears to play a functional role that we have not associated with any other gene, and it occurs in close proximity on the chromosome with 5 other genes from the same subsystem. The function of genes having the same functional roles have been described in Enterococcus faecalis (10529184), Saccharomyces cerevisiae (1511880), Lactobacillus plantarum (8982065) and Bacillus subtilis (10545205, 1709162). These are homologous proteins which implement the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.